Blar i forfatter "Sabri, Osama"

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    • Preclinical incorporation dosimetry of [18F]FACH—A novel 18F-labeled MCT1/MCT4 lactate transporter inhibitor for imaging cancer metabolism with PET 

      Sattler, Bernhard; Kranz, Mathias; Wenzel, Barbara; Jain, Nalin T.; Moldovan, Rareş-Petru; Toussaint, Magali; Deuther-Conrad, Winnie; Ludwig, Friedrich-Alexander; Teodoro, Rodrigo; Sattler, Tatjana; Sadeghzadeh, Masoud; Sabri, Osama; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-26)
      Overexpression of monocarboxylate transporters (MCTs) has been shown for a variety of human cancers (e.g., colon, brain, breast, and kidney) and inhibition resulted in intracellular lactate accumulation, acidosis, and cell death. Thus, MCTs are promising targets to investigate tumor cancer metabolism with positron emission tomography (PET). Here, the organ doses (ODs) and the effective dose (ED) of ...

    • Sigma-1 receptor positron emission tomography: A new molecular imaging approach using (S)-(-)-[18F]fluspidine in glioblastoma 

      Toussaint, Magali; Deuther-Conrad, Winnie; Kranz, Mathias; Fischer, Steffen; Ludwig, Friedrich-Alexander; Juratli, Tareq A.; Patt, Marianne; Wünsch, Bernhard; Schackert, Gabriele; Sabri, Osama; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)
      Glioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to recent research, the sigma-1 receptor (sig1R), an endoplasmic reticulum chaperone protein, is involved in signaling pathways assumed to control the proliferation of cancer cells and thus could serve as candidate for molecular characterisation of ...